Thank you for your interest in supporting the Breed Life UCLA Stem Cell and Kidney Transplantation Fund.
Kidney transplant has saved the lives of thousands of patients with end stage renal disease. In spite of its enormous benefit, transplantation nevertheless still has two major challenges: the risk of graft rejection and the need for lifelong immunosuppression. Because of graft failure related to immunological rejection, many patients must return to dialysis and/or undergo a second transplant. Chronic immunosuppression is required to prevent graft rejection but is itself associated with a host of serious and potentially life threatening complications. These include infections, malignancy, hypertension, diabetes, heart disease, and paradoxically recurrent kidney failure.
It has long been the dream of transplant scientists and physicians to discover a solution to the problem of graft rejection and the heavy burden of chronic immunosuppression. The kidney transplant team at UCLA is developing a program to combine kidney and hematopoietic stem cell transplant to create a state of immune tolerance in which the patient’s immune system will not reject the transplanted kidney and there will be no need for ongoing immunosuppression. Based on previously established successful protocols, they intend to pilot this approach in patients receiving human leukocyte antigen matched living kidney transplants and then extend it to deceased donor kidney transplants and subsequently to other organ and vascularized composite allograft recipients. As one of the three largest kidney transplant programs in the United States and with a wealth of clinical and basic science expertise in transplantation, UCLA is in a unique position to make a major contribution towards realizing this dream.
UCLA will work with top experts from Stanford and other medical institutions to train clinical technicians and surgeons on this process. We are planning our first stem cell kidney procedure at the end of 2017. This is not yet FDA approved therefore our start up cost is $100,000 and our goal for 2017 is $250,000. Time is of the essence. This groundbreaking work will save thousands of lives. To learn more or to support this transformative endeavor by Breed Life and UCLA, please contact me at 818-388-8246.
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From the Heart Pro (Breed Life’s Fiscal Sponsor)
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